The Romans gave to this Park the name of "Monfragum" (Fragoso Mountain), but already was inhabited in previous centuries by the people before the Romans, which returned account of sound not by this zone in various remainders of burials. However, there is certainty of payments which go up at the time prehistoric. Tests of that let us find we them in the cave located close to the Castle, where one can observe cave paintings and funerary wakes of the Bronze age. The Moslems also occupied this zone, by changing its designation, at at which are put to call "A Monfrag".

The Moslems leave with his step that which is today the elements most representative and knowledge of the park, the Castle of Monfragüe. Also, the various kings who occupy this territory subsequently were gradually while returning account of their presence. The kings of Leon left the zone between the hands of the Santiago Order, which will be that which raises the hermitage to keep the image of our injury of the Gandío Mountain during the reign Felipe II. Reign of Sancho IV, one preserves the Bridge of the Cardinal, who as his name indicates, it was sent to build by the Cardinal Juan de Cardinal, in 1450. In the first centuries of the reign of the House of Bourbon, one reinforced the monitoring on trade route which crossed with assistance of caravans the Coupe River and which by that one linked Trujillo with Plasencia then. That was the reason this why century XVIII one melts Villareal de San Carlos, currently one of the information centres of the park.

As the last makes determinant clearly we cannot cease mentioning creation during the Sixties of the Alcántara prisoners and Torrejón, which made disappear a great quantity from animal and vegetable species in connection with the zones of Split. In 1979, April 4, Monfragüe is concretely declared Natural reserve and in 1988 Zones of Special Protection of Birds.

In 2006 it has been, finally, declared National Park.